Lack of single key Home/End and forward delete etc. All are somewhat possible with the Fn key, but that makes crazy combos and go to start/end of line also is a pain...
If you use Wordstar bindings, then control+q,control+s is start of line, control+q,control+d is end of line. Forward delete is control+g.
The Wordstar, Emacs and Vi keyboard bindings evolved in the days before dedicated keys for cursor movement functions, so they are useful as long as you have the requisite additional modifier keys. I.e., like when you are on a laptop with a limited number (or none) of dedicated cursor movement function keys (or with those same keys hidden behind odd Fn keystroke combos that differ between any two different laptops).
ctrl+a goes to the beginning of a line ctrl+e goes to the end ctrl+k deletes a line
There's also a lot of other possibilities with plugins for a given editor, like Vim-style bindings in Sublime.
I haven't yet found any real restrictions in my workflow once I learned some of those.
Take a look at the shortcuts in nano; pretty simple stuff can help a lot. Ctrl + Y = page up. Ctrl + v = page down. Ctrl+x = exit.