Sacrificing most of the fun but not productive activities that fill the hours of less-ambitious young people (video games, TV, social drinking, chasing tail) is reasonable (I haven't had a drop of alcohol, or been on a date, in months). An occasional 5-hour night of sleep can be justified by a freakish, almost hypomanic productive streak. Sacrificing one's health for work is idiotic, and going 7 years without taking a vacation is nothing to be proud of.
[Edit: I developed panic disorder from working through a severe flu, in an overbearing environment. I'm still on meds, over a year later. So I have personal experience to support my claims.]