I'm pretty excited about the latest release of ClojureScript that makes all this possible. With respect to speed of incremental compiles, code size, performance of generated code, and debugging we're finally in a good place (with of course many improvements planned in the near future).
None of this would have been possible without the tireless work of 62 contributors over the past two years, http://github.com/clojure/clojurescript/. A big thank you to all!
Happy hacking!