I'm in this bummer of a situation where I can work remote from pretty much anywhere I like, but my wife is bound to her 9 to 5 that won't allow her to work remotely for more than a few days at a stretch. She does knowledge work as well, and if she had been with the company for a long time and was super essential to the business they might let her work remotely for the long term, but because she's somewhat replaceable if she goes anywhere too long, she loses the job.
Its a real problem because we need to be back on the other side of the country for family at the moment and she's trapped here by the company HR policy.
Really hoping that this stuff starts to break into mainstream corporate acceptance soon. These older companies are pretty sluggish to adopt remote worker policies, especially for jobs that they can just as easily fill with people on-site.