The Silk Road seizure demonstrated that the only reasonable way to participate in any online drug market is to assume the market itself is compromised and untrustworthy. That means you never upload identifying information in cleartext (e.g., buyers encrypt their addresses with the seller's public key), and you run all bitcoins sent to or received from such a site through a third-party mixer.

Of course, there still has to be some level of trust on the part of a buyer, that the seller they're connecting to is actually a real drug dealer and not an undercover cop. But that was still an issue even on the original Silk Road. It was partially addressed by the feedback/review system -- which does involve a certain amount of trust in the site not to fabricate reviews -- but more importantly by the fact that high-level law enforcement is really only interested in tracking down sellers. And assuming the users are competent, running a honeypot gives you very little information about the sellers.