Can you recommend incubators/accelerators based on Charleston ? a quick gsearch revealed a few, but can't seem to find successful startups graduating from them.
Silicon Prairie is booming right now. Kansas City, Nebraska, Iowa, etc all have people both investing in companies and starting companies.
Invest Nebraska, for example, will give you $50,000 if you provide 50% from other sources (So you'd need to find $25,000 on your own before they'll give their $50K to your company. )
Cambridge, MA is an option - there is a great ecosystem here. Although my understanding is that east coast investors are more "conservative" than west coast early-stage investors and VCs.
My friends in Portland and New York seem to think things aren't quite as "crazy" out there.