How is library support? I didn't have any issues with django 1.5 itself, but many of my favorite libraries weren't ready yet.
From personal experience, most of the critical ones are compatible.
Of course I'm partial to my new pave project: https://bitbucket.org/mixmastamyk/pave It is based on fabric, and uses a yaml file to automate it.
Still in progress, but there you go.
There's always the option of just using Upstart or systemd as well.