I am not an economist and I'm not going to bet $10k on it or anything, but I think it's reasonable to expect something to change the situation.
Unless you mean, say, production of ionizing alpha radiation, capture and containment, in which case you're using up another scarce resource of radioactive source products, generating far more radioactive waste then existing dirty nuclear plants, all for an amount of helium that you need a laboratory to measure.
Or maybe you mean by fusion? In which case you'd need a fusion reaction which yields stable helium isotopes which can be extracted without including radioactive byproducts. The difficulties here make interplanetary trade seem like nothing.
Economics is not a magic bullet. You actually need viable choices first, which we don't have here.
As far as I can tell, all natural gas resources has a percentage of Helium. Since we won't be running out of natural gas anytime soon, we won't be running out of extractable Helium. It just isn't extracted right now because the US is dumping their stockpile. By 2015 this should be done, prices should spike because production was stopped and will take some time to restart, and then it'll go back to "normal".