Even if you're inclined to argue that this style of programming doesn't lead to a giant mess (and I'm inclined to believe that it does, even if you are the most disciplined of programmers) I still don't see the benefit of adding this 1K of JavaScript to my page at all. I can duplicate $.observable with a vanilla jQuery object.
To call this the "most powerful client side framework for building large scale web applications" is downright laughable.