It is perfectly fine to not squeeze every drop from your hardware and pick Go or Lua. In the same vain, Flask may be x20 slower at a meaningless benchmark but you'd note that the ones that involve actual work, you know, the kind your complex app will actually perform, the more involved it is the more the difference shrinks. All the way down to x4, in other words not an order of magnitutde.
The real takeaway summary should probably be: a well made framework like flask doesn't have so much overhead that the productivity gains it offers are not worth trading a bit of performance for.
A terribly made framework (I won't name names) will bite you in the ass. Choose carefully.