This list makes the rounds every year or so, but I always like seeing it; one of the domains is a special one to me, although I was not there at the time it was registered. UniPress Software (unipress.com, #80 on the list) was my first job while in college in the late 90s, and gave me the ~14 year experience of creating a product that went through all of the stages from "figuring out if people want a web-based application that does ___" to being a grown up, enterprise software that was acquired by a very large company. The two founders had real software-startup instinct before startup/entrepreneur was something written about, a love for what it is that we do, and are still close friends. It was a great place to be, a great time, and awesome people to be around. The two founders reached the age of retirement and sold the company years ago, but have been involved in two startups since, just because it's what they like. It makes sense that they would have bought a domain when it was a "pioneer" thing to do.
Most recently, seeing that Twitter was becoming very popular, Mark had been pumping out PHP code using CodeIgniter and made www.mediaroost.com in his spare time, a Twitter Management platform. It didn't take off, he retired it, but had a good time. Going way back, this is the same guy who wrote C compilers and sold Whitesmiths Ltd which released the first commercial C compiler.
(and going back before my time again, but interesting history - UniPress had also purchased Gosling Emacs which then became UniPress Emacs, controversially asking Richard Stallman to stop distributing GNU emacs source code.)