I used to do the bulk of my prototyping with Python + Django + JQuery + Postgres or AppEngine Datastore. Of late, I've switched a lot of it to just straight HTML + Javascript + a JSON feed from backends. If I need server-side computation, I'll build a quick Go or webapp2 app on AppEngine. I work just as fast if not faster, and there is far less that can go wrong. I'm not constrained by the idioms of the framework in development (this is a major problem with MVPs - all Rails/Django apps seem to end up looking like a bunch of forms over a database, even if that's not the best interface for users), and if one of the approaches works, I have an easier time productionizing.
For my most recent prototype, I started with JQuery (as usual) and then quickly end up removing it when I found that everything I used to use it for is now built into the browser. $ = querySelectorAll; .on = addEventListener; .addClass = .classList; .animate = CSS3; .ajax = iframes. And all of the browser native stuff runs significantly faster, and doesn't require that you download 90k of JS each time you want to refresh.
It's not 2006 any more. You can pretty much prototype in Webkit only, most of the things you need are built into the platform, there are easy minimalist libraries that will let you setup a JSON feed out of AppEngine with barely any code, and JS on the client can do pretty much everything. At least until you start caring about latency, but by then you're out of MVP range.