Ask HN: Help finding a challenging, meaningful job?

I am looking for a new career opportunity, and a rather specific one. I already have the job that most young programmers want, with a ridiculous salary and benefits package.

I want something challenging that could change the world. I have had major cancer twice and survived; I simply can't find it in me to glue together mockups for a random cubelet of the Borg. I have 15 years of experience doing many diverse things in the software world.

I want to cure cancer. I want to use creative, out-of-the-box ways to solve the world's biggest problems. I've been told my entire life that I have a unique ability to solve problems that others can't, but I almost never get to use that ability.

I don't know how many years I even have left to live (probably more than 10 :)). I need somebody to take a risk on me, and throw brutally hard problems at me, and see if we can't just make a difference.

Please, if you know of such an opportunity, know of somebody who does, or know me enough that you're willing to create one for us, respond to this post.