I have a Windows 7 desktop and occasionally I might run a scan from an antimalware software. That's as far as I'm willing to go, I don't install special av software because they consume a lot of resources especially with real time analysis.
EDIT: Furthermore, if you’re a tad paranoid you can enable AppLocker in Windows to eliminate any chance of an unwanted program wreaking havoc on your machine. Anything that’s not signed by a company you approve doesn’t run.