Not just advantages - some organisms rely on extremely complex symbiotic relationships and environmental stimuli (e.g. fungi in the genus Morchella). Reproducing these conditions, even with advanced technology, could be extremely challenging or impossible, which could create enough demand to justify physical transportation of goods. (This is essentially the plot to the science fiction novel I'm writing.)
That was the main idea in Frank Herbert's Dune - "the spice". It's a good strategy to follow a tested winning idea, good luck with your writing!
With even informational signals taking years to decades to centuries each to reach their destinations, our current knowledge of physics implies that a civilization basically needs to achieve indefinite cultural lifespan before they can do anything interstellar whatsoever.
So once you've got people who can maintain records and culture over centuries on detailed matters (or who just plain live that long), it's really not that much of an obstacle. But it's a nastily high mountain to climb in terms of bootstrapping your interstellar empire.