Be sure to talk to the ham radio guys and RC car guys first, who have a couple decades experience with almost uncountable number of DC power "standards", or you'll just poorly reimplement something they already figured out back in 1970 or whatever.
The Anderson Powerpole seems a rather effective and cheap way to shove a couple hundred watts of DC around. Of course there must be millions of existing connectors all operating at 12 volts so applying it to a 5V standard will be problematic at best. I have them all over my house given my electronic interests. Do NOT listen to people who complain about them, much like the legendary PL-259 connector or soldering SMD device by hand, 99.99% of the population just does it no problem without drama but the 0.01% who can't be bothered to learn how, make sure to very loudly tell everyone about how it never works, etc. Its tiresome but traditional.
The molex family seems most effective at demonstrating the flammability of overheated nylon, at least at power levels over a hundred or so watts.
The ancient Cinch plugs worked sorta well, although they're a bit large and fiddly.
Coaxial DC connectors are something of a standard although few can handle a hundred watts, at least at low DC voltage.
A miniaturized version of the standard used for intelligent electric vehicle charging would be interesting. There's probably a patent preventing innovation, but maybe in a few decades when existing patents run out thus permitting innovation to start again...