Typically. For example, on reddit you can run this in console to downvote everything on a comment thread:
$.each($(".down.arrow"), function(index, vote){ $(vote).click(); });
$.each($(".down.arrow"), function(index, vote){ $(vote).click(); });
Either way, it's probably a good guide to follow if nothing else -- I mean, reddit still has near-daily capacity issues.
So the above could be written:
$(".down.arrow").click();