Thinking of opportunity costs in general is usually a downer in
any context. It's a "could have" and wherever there is a "could have", a "should have" is not too far behind. Regret is never a good thing.
Also, a lot of people recognize that time is money, but rarely do they think that money is time. They never use their money to buy back time. Instead they use it to make more money. And now they have to spend more time protecting, managing and investing that money because if they don't, they'll feel bad about the opportunity cost of their money sitting in the bank and being eroded by inflation.
And enough people know how to earn money, but most people don't know how to spend it. When I say spend, I don't mean waste or reinvest. Consider: if you give someone X dollars, he will start by eating better food; give him 2X and he'll dress better; 3X and he'll buy a better car; 10X, a better house. This is usually where people's imagination start to fail them. 20x? Er... buy an even better car and a better house. 50x? Buy two cars and two houses. 100X? Buy a yatch. 200X? Buy a private jet.
Notice that after the lower levels of Marslow's hierarchy have been satisfied, people just don't know what to spend their money on. All they can think of is buying bigger and bigger versions of what they already have. You can't eat away a $100 million no matter how much expensive food you eat. You can't live in all the rooms of a 50-room mansion. All you can do is use your money to make more money or waste it. Not many think of spending it to buy back your time -- spend it doing something you like.