Probably worth mentioning that there is also the CSS Grid Layout Module [1], which has (according to Can I use...) much less support (9.65% [2]) vs Flexbox (79.32% [3]). A quick survey suggests that Flexbox should be used 'in the small' whilst grid is for 'in the large', but Solved by Flexbox seems to suggest that it is equally competent as a solution for whole page grid layout. Is the CSS Grid Layout module a dead end?

[1] http://www.w3.org/TR/2013/WD-css3-grid-layout-20130910/ [2] http://caniuse.com/#search=grid [3] http://caniuse.com/#feat=flexbox