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tl;dr: not with GPU but possible with ASIC

And possibly not with ASIC given the potential of multiple vendors worth of ASIC's coming online at roughly the same time. I believe at least one has shipped the bare hardware.

Several have shipped, including Butterfly Labs (although they're still backordered). Here's a review http://arstechnica.com/gadgets/2013/06/how-a-total-n00b-mine... Looks like they'll be profitable for a while yet.

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