I recently moved from San Francisco to South Carolina. San Francisco is often derided as a city of eternal adolescence, whose residents still live with multiple roommates, party at odd hours, switch jobs often, don't think too much about the distant future, and disvalue stability. In contrast, traditional adulthood is alive and well in South Carolina. There's a counterculture, but overall SC is much closer to Leave It To Beaver.
SC has some merits, but personally I'd take SF over SC any day of the week. It is more fun, and it's also contributing much more to technological and cultural advancement, the creation of wealth, and the economy overall.