My wife and I had one of our wedding pictures take the number one spot on /r/all one day -- There was some rather embarrassing text super-imposed on it that said "Oh you think married women still give BJs" (google Condescending Wife to find it).
Despite some of the comments in the thread being pretty mean, my wife and I took it in stride, we're both internet people, we get it; we thought it was pretty funny all things considered --
The awkward part of all of this though, was this picture was EVERYWHERE for about a day. All over Facebook, Tumblr, etc. So countless friends and family inevitably saw it. I got a call from my concerned father, asking me if everything was ok and if I had seen what the internet had been saying about me and my wife. I explained to him that we didn't really mind and we left it there as explaining reddit to him would have been near impossible. But it was just a really surreal experience. We got dozens of texts and emails that day all asking if we had seen the picture.
The best part of the the internet's short term memory is how quickly this image found it's way into obscurity; to be completely forgotten. No ill harm to my wife's nor my reputation.