Since new anti-biotic development is so critical, I don't get why the feds don't in-source it to the CDC or provide massive incentives already. This is an infuriating problem that should've been dealt with decades ago on the R&D-funding front.
Antibiotics were originally discovered accidentally, and a lot of subsequent antibiotics were discovered/created by investigating and extending the mechanisms of the original discoveries.
We're now running out of those implications to chase down. To get the "next breakthrough" in antibiotics will require another surprise discovery, or some other fundamental breakthrough in basic biological understanding.
1) its been a number of years so this might not be accurate anymore if it once was