Having done this a bit, the answer is in my experience, figure out a good location in a particular country, in Thailand I'd say Chiang Mai, in China perhaps Yangshuo, Cambodia Siem Reap or Sihanoukville. Get yourself a cheap place/room for a month or so, do some serious work then when you've completed whatever it is you're doing do some proper traveling.

Trying to do it all at once is mostly a killer. That's not to say you can't do maintenance and smaller tasks while actually traveling, but really building anything meaningful actually requires a lot more concentration in my opinion.