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My method for doing this involves writing gibberish into or deleting content from a jpeg opened in HexFiend

It's very trial and error, but the results can be fun when you screenshot each progressive glitch and then gif them together to get stuff like this:

Neat that someone automated the process, though.

After a fair amount of trial-and-error hand editing I devised a simple Ruby script to auto-glitch.

Later I combined this with another script to gather up the generated images and create an animated GIF.

Very cool! Going to check this out.