The Kinesis Advantage line is fully remappable, including macros. It's also premium hardware (nice switches) and a supremely ergo layout, with most keys within reach of the home row, and the thumb region divided up into multiple frequently-used (remappable) keys:

http://www.kinesis-ergo.com/advantage.htm

Don't be cowed by the esoteric appearance; it's really just a tweak on the standard layout.