Ask HN: What do you use for your typography base?

With a vast selection of CSS frameworks out there and a number of helpful tools, I couldn't but notice there is a lack of good typography base out there. Maybe I just can't find one, and I am not an expert in the field.

I'm talking about a good base for readability on blogs and larger amounts of text (like documentation or stories).

So, what do you guys use/prefer? I think a combination of what readability does with wikipedia would blend in nicely.