I think the next "Big Thing" is that we are going to start moving more and more toward Augmented Reality (AR) [1] and Virtual Reality (VR) [2].
Thoughts:
1. Look for gaming to start heading in the direction of VR with technology like Oculus Rift [3]. Also, with someone of the caliber of John Carmack [4] involved, with not only his passion and skill, but his ability to work with graphics hardware manufacturers and driver developers to effect change and garner the necessary support and backing, expect to see vibrant, compelling developments in this field.
Here is a video of John discussing some of his VR work. It is from E3 2012:
https://www.youtube.com/watch?v=NYa8kirsUfg
2. Look to see more games like Ingress [5] as things start to move toward AR.
3. I realize that this may be an extreme, perhaps well-into-the-future example, but check out this short film entitled, Sight. It is not difficult to imagine that this is where we are heading with technology like Google Glass (e.g., Note in the film the gamification of things like cooking and dating. Personally, the dating part is scary.)
https://www.youtube.com/watch?v=lK_cdkpazjI
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[1] https://en.wikipedia.org/wiki/Augmented_reality
[2] https://en.wikipedia.org/wiki/Virtual_reality
[3] https://en.wikipedia.org/wiki/Oculus_Rift