Genetically modified crops pass benefits to weeds
nature.com
nature.com
I read the original article, and Wang et al. measure fitness by (i) measuring photosynthesis in glasshouse-grown plants (ii) measuring seed germination on wet paper in petri dishes and (iii) growing plants in garden (grown 20 cm apart, fertilized, hand-weeding and insecticides applied).
We probably can assume that the extra copies of EPSP synthase genes increase the metabolic throughput (by boosting some of the protein synthesis pathways) of the plants, and when grown in abundant light (20 cm apart, no shadowing and competition from neighbouring plants), water and nitrogen (grown in garden conditions, fertilized), it is plausible that these individual grow faster and larger. This is all that Wang et al. did and all that their article claims.
The higher throughput capacity only comes into use if supplies of energy or raw materials are not bottlenecks.
But the Nature News conclusions "effects of such modification have the potential to extend beyond farms and into the wild" and "genetic diversity [of wild rice], which is really important to conserve, could be threatened because the genotype with the transgene would outcompete the normal species" are very much unsupported by the results of Wang et al.
In the wild, seeds may need to germinate in more challenging conditions that wet paper on a petri dish, there may not be abundant light, nitrogen or water.
So the EPSP synthase -boosted plants grow better in the garden. But maybe there is a good reason why the EPSP synthase levels are lower in the plants from the wild. Maybe something else is more valuable to them, something that helps in e.g. low-light photosynthesis, nutrient or water uptake in scarce conditions, or defence against insects. Maybe the wild EPSP levels are just optimal for growing in wild conditions and the plants with boosted EPSP synthase levels would have lower fitness in wild conditions. (I assume that the higher levels of the synthase don't come for free, but have a related metabolic cost that cannot then be used elsewhere).
As Wang et al. only measured fitness in garden, not in the wild, the Nature News conclusions are unwarranted.
In poor soil, adverse weather, etc these adaptations might make the plant burn itself out too quickly like a sprinter in a marathon race. The emphasis on growth might weaken it's immune system, or make it more susceptible to disease in other ways.
I'm always interested in these studies on how engineered changes interact with the wider ecosystem and make their way into other organisms. I'm not dissing the research, it sounds like a valuable study, but finding potentially advantageous changes in the lab and finding those changes actually confer an advantage in the wild are two wholly different things.
Thank you for a very valuable comment. It's nice to see understanding of plant ecophysiology in Hacker News.
So, I went to the original article [1] and this is about how they measure fitness:
"Measurement of photosynthetic rates [...] We used glasshouse-grown GE and non-GE F3 plants"
"Seed germination experiment [...] Seeds were germinated on wet filter paper in Petri dishes."
"Field experiments [...] Common garden experiments were conducted [...] 36 plants were planted in a 6x6 grid with 20 cm between plants [...] weeds were removed by hand-weeding [...] urea (nitrogen) per 100 m2 was applied [...] Insecticides that are commonly used in rice fields were applied"
So, fitness is measured in (i) glasshouse (ii) on wet filter paper in laboratory and (iii) in garden conditions, with fertilizers and insecticides applied.
Now, the original article doesn't claim anything beyond that, and a case can be made that the natural environment of a weed is in in the rice field (with fertilizers and insecticides), but the Nature article says "effects of such modification have the potential to extend beyond farms and into the wild" and like you said, measuring fitness in glasshouse/lab/garden conditions tells pretty much nothing about fitness in the wild beyond farms.
[1] http://onlinelibrary.wiley.com/doi/10.1111/nph.12428/abstrac...
There has to be a downside that this study didn't pick up. Perhaps the change makes the plant more attractive to pests?
I might guess that competitive advantage only apply where weeds are bad: in fields. Before fields there were no advantage to this.
e.g., There's presumably a gene out there that makes humans twice as intelligent at absolutely zero expense, and although if it were to appear it would be selected for, it it clearly hasn't happened yet. Natural selection can't drive that to occur.
Btw the answer can be yes. We are no longer constrained by food concerns but our genome does not account for that yet.
Duplicating a gene should be well within the capability of normal evolutionary processes.
I wonder slightly at what point an plant still inhabits the "invention". 99% genetic similarity to the patent? 10%? 1%? At what point does it losses the attribute of being the property of Monsanto?
And I want roundup away from my plants and my environment. Thanks.
I love how PR could twist a bad to make it a good. Hey, we don't have a way to control our GM crops contaminating other crops!! How great is that! By the way,pay me for using my intellectual property that is in your crops even when you don't want it, as it is a benefit for you.
The reality is quite simple: our soils are going to end up looking a lot more like they did in the past (doused with nasty chemicals; stuff that will make environmentalists miss Roundup).
Despite the flaws of GMO crops, our soils in the Midwest are about as clean (in terms of pesticide/herbicide) as they've ever been during industrial agriculture. (Yes, yes, I realize the fertilizer situation is dire -- that is a separate problem and a massive area for research & innovation)
Agriculture is and always has been about chemical warfare. Plant and insects evolve over seasons. The only difference is that now humans are helping plants along. And yes, I emphasize "helping" because I see zero potential in non-GMO crops feeding humanity in the long run. It is one thing to grow tasty heirloom tomatoes in your yard and quite another to produce commodity grain at scale sufficient enough to meet global demand. I hear so many armchair environmentalists equate the two; very frustrating.
But grain is such a process and such an amazing supply chain. I don't see that being replicated.
I have a degree in biology. I'm sympathetic to the activists even though I do not agree scientifically with many of their claims. Thing is that I can see why they are skeptical of GMOs and why they do not trust the companies making them, and I don't think their reaction is especially irrational.
And I've always been skeptical of GMOs for different reasons. I studied evolutionary biology a lot, and the set-up that you get with GMOs always struck me as similar to the set-up you get when you over-use one single antibiotic. At first it works beautifully, but then the bugs adapt. In this case the entire ecosystem adapts.
Transgenes are natural. Horizontal gene transfer happens all the time. This destroys a lot of the BS claims of the activists, but it is also a problem for the supposed benefits of GMO crops... as we see here.
I also think the issue of patents and self-reproducing organisms is a legal hell-hole.
In a way, this is nothing new. When Norman Borlaug was working to save the couple of billion lives with his green revolution, also his plant breeding methods (which we now see as traditional, totally natural and acceptable) were often seen a unnatural and potentially dangerous:
"Throughout his years of research, Borlaug's programs often faced opposition by people who consider genetic crossbreeding to be unnatural or to have negative effects."
http://en.wikipedia.org/wiki/Norman_Borlaug#Criticisms_and_h...
"I also think the issue of patents and self-reproducing organisms is a legal hell-hole."
There actually exists plant breeder's rights for traditional (non-GMO) varieties, so the situation with patents may not be so much different:
At the same time, there are some long-term criticisms that are not mentioned here. Borlaug's methods are almost entirely reliant on fossil fuels for example, so there has long been a criticism that he simply delayed the inevitable. When the fossil fuels run out, modern agriculture will collapse.
Right now that is definitely true. It would be possible to evolve technologically to the point that it isn't, but so far that's been a slow slog.
There is a similar criticism to be made about present-day GMO tactics, and I allude to it in my OP: they buy temporary wins but are not sustainable due to selection effects and horizontal gene transfer diluting them over time. A lot of the ecological/sustainability crowd are basically arguing that we have to look for permanent solutions, not temporary gains, and that temporary gains have a way of degrading the environment in ways that make permanent solutions more difficult.
What it really boils down to is this:
http://citizenactionmonitor.files.wordpress.com/2010/06/worl...
If that graph doesn't scare the living shit out of you, you aren't thinking about it very deeply.
Is this a permanent shift, or is it a bubble? If it is a bubble, its collapse will result in suffering beyond our capacity to even imagine.
We fertilize crops, especially with nitrogen, because the triple bond in atmospheric N≡N is a tough nut to break. We use chemical engineering (in this case, high pressure and heat, google Haber-Bosch process) to fix the nitrogen from the air on behalf of the plants.
This requires energy, but any cheap energy would do, it doesn't need to be from fossil fuels.
Nature, animal and insect life, is far too chaotic a process involving too many interactions, for them to know what long term effects "weeds that glow in the dark" will have (Let's adopt GMOs! It's from the guys that brought us Thalidomide!). So they mostly experiment in real life, with government regulatory bodies that are easily bought or swayed.
(And no, the "overpopulation that needs to be fed" defense that's often used is mostly BS. For one, they could not care less: they patent their work to death and charge a premium for the seeds to poor third world farmers -- as drug companies do with AIDS drugs etc. Second, the main use of those techniques it to make food for the first world, sold to the same people that always had food, have higher profit margins).
As for the reason a lot of people in the tech etc community are pro-GMOs, I think it's two-fold:
For one, they react to some rather poor arguments from the anti-GMO crowd, that, as any large crowd, also contains ignorant people, neo-hippies, etc. So they throw the baby (caution and scepticism) with the bathwater (ignorant claims).
Second, they confuse engineering (including GMO engineering) with science, and think that by defending any random money-grabbing work of engineering they are defending "science" against the ignorant masses. They make an ego conpensating psychological mechanism out of science, like religious people do with religion.
That it a somewhat cheap shot. Yes, science makes mistakes. But I don't think switching over to the anti-vaccine, homeopathy-supporting type of crowd results in less mistakes.
What I don't like is hastily done applied technology that pretends to be science, but instead of knowledge it caters to money interests and the need for a quick buck. And the people that go "Oh, science was used in the process of creating this, we must defend it" (hint: science was also used in creating cigarettes and high fructose corn syrup).
Science is about learning. Those kind of endeavours, like Monstanto, is about locking-down and selling -- and let the future generations sort any bad outcomes out.
They can (and do) sidestep scientific rigor, objections, methodological issues, and the need for long term impact studies (and of course, all the ethical and societal issus arising from a company patending seeds themselves) to the maximum extend that regulatory bodies allow them.
This is IMHO a really major reason for opposition to GMOs: people do not trust the "establishment" in general anymore.
I actually hear someone say once: "if it comes from a big company, it's about fucking you over or taking your money." People have a sense that they are serfs and that overtop of them are a bunch of feudal lords rubbing their hands together and cackling about new ways to impoverish, poison, or otherwise stick a boot in their face.
This perception has many bases, but ultimately I think it's an emotional reaction to the contemptuous treatment that the public receives by way of the political class and the PR industry. When you talk "down" to people and treat them like idiots, it foments contempt. This contempt is expressed through distrust and suspicion.
And there are certainly people who fit the "cackling feudal monster" stereotype. I don't believe they are in the majority, but there are enough of them to create a bad impression. Keep in mind that human beings give excessive weight to negative examples. If you walk through a neighborhood and someone mugs you, you will forever consign it to a status as a "bad neighborhood" even though 99.99% of the neighborhood's residents would never do that. The same goes for elite deviance. A single Bernie Madoff creates the same perceptive effect as an entire ruling class made up of Bernie Madoffs.
Also e.g. social networks and cell phones come from big companies, but for some reason no one is suggesting to ban the technology that they are based on.
(1) The researchers did NOT observer genes crossing over from the GMO to the wild, weedy form of the rice in a Natural setting.
(2) The authors argue that the new genetic material, if it were to escape into the wild, would reduce genetic diversity and that this would be harmful. But by the very nature adding a new gene, genetic diversity has actually been increased.
What you say is true, they didn't observe than. But weedy rice (Oryza sativa f. spontanea) is the same species as rice (Oryza sativa), so gene crossing is not far-fetched, it's to be expected in any case.
A botanist can't examine a plant and tell if it is a weed. A chemist can examine a liquid and determine if it is water.
This is because, despite being a common language term, "water" maps to a specific chemical compound.
"Weed" is a common language term that maps to nothing in a scientific context. RoundUp is an herbacide, it only becomes slective, i.e. "a weedkiller" when some plants are genetically modified and this because we define "weeds" as whatever plants Roundup kills.
The set of weeds for a horticulturist is different from the set of weeds for an agronomist and both are different from the set of weeds for an ecologist - and more importantly, the horticulturist's weeds and the ecologist's weeds will tend toward polar opposites.
The same is of course true with the agronomist. Thus a natural food bearing plant is described as a weed in the article.
The premises upon which the article are based are economic not scientific despite the name of the publication.
That's "pure water".
In 99.999% of the cases the term "water" is used as the impure mixture of H20 with tons of added substances, from fluoride to sodium, magnesium etc.