We elaborate briefly on various related work at http://yang.github.io/reactive-coffee/related.html, but absolutely - there's a large body of existing work and trailblazers we liberally draw inspiration from. In the case of RxJS in particular, the styles actually feel quite different - RxJS is more about explicitly merging streams and constructing the data flow graph with some set of combinators, whereas dependencies are inferred automatically in reactive.coffee (along with a UI-building layer).
We're also strong believers that the entire stack can be architected in this way. Stay tuned! For now, check out projects like Fun, Ur/Web, and Meteor/Derby:
http://marcuswest.in/essays/fun-intro/