These all seem prime candidates for some kind of learning algorithm (at the very least a naive one). Like TCP's window size scaling, just for settings that are too complex to bother with tuning.
> the default settings have been tweaked by domain experts
> over decades to be reasonably good for the general case.
Yes, but look at default configurations such as those of Apache and Mysql - you'll find that the default settings have been finely honed for environments that were common ten years ago... Even settings need updating - optima are moving targets.