Either you're trolling, or you are...very confused. Giving you the benefit of the doubt........
You're looking at a django project template which is based on Python, Django, Postgres, a traditional response cycle, and asking how to swap out every single component, leaving literally nothing of the original project. The answer to "how do I do it" is "by rewriting the entire thing, from scratch".
Worse, you say "the point is to be production ready", but what you're suggesting is to rewrite an app written on a very stable, very battle tested stack with one written in the latest hipster frameworks. For something like this project, BY DEFINITION what you're asking will make it less production ready. Even if we grant that MongoDB or NodeJS is useful for production in some circumstances (and in the case of MongoDB, that's actually an open question, but I digress), it ain't these.
There's a stereotype that the average HN commenter is obsessed with hipster technology like MongoDB and NodeJS, and wants to use them even when, as here, they aren't appropriate. In addition, the stereotype also holds that the same commenter is probably into bitcoins (which you mentioned), loves scaffolding tools like Yeoman (which you mentioned), and indigogo projects (which you also mentioned). All of this just screams "troll"; the only false note is your mention of NoFlo and the k-12 demographic; unless I've missed an influx of hipsters, tha's the one line in your post which doesn't sound like a parody of the stereotypical HN commenter.
So...yeah. If you're a troll, you're a good one. If you're being serious, you need to step away from the Kool-Aid because you honestly sound like a walking parody. The technologies you mention are not silver bullets, and in no way "production ready" compared to a traditional webapp. What you're asking about is both impossible and a terrible idea.
And that's why you're getting downvoted.