I understand why Keep-Alive exists, but I think HTTP is just the wrong place. I don't believe that the round-trip latency shouldn't be an issue. It simply creates too much complexity for what is suppose to be a simple protocol.
> I think all it'd take to change your mind is to load Facebook or Twitter with SPDY and Keep Alives turned off...
I also believe that those sites are loading way too many resources. I'm also not against SPDY, but I don't think it should be HTTP. If someone wants to use SPDY, then so be it.
EDIT: Actually, I just loaded Twitter and Facebook with HTTP 1.0 (No Keep Alive). It was a bit slower, on the order of a handful of seconds, but nothing that I would consider terrible. These are also some of the heaviest sites a browser is going to load.