At some point an individual has to come to terms with the fact that 99% (or some equally large percentage) of human economic activity has nothing much to do with improving the human condition, but is rather beer and circuses writ large.

You can cure a disease for the cost of a large video game development these days, and an election year of political donations in the US could be used to cure aging. Medical research in general is a sliver of the economic activity spent kicking leather balls around grassy fields.

This is the world. The only way to make it better is to do what you can to add to the sliver rather than to the circuses.