These (
http://www.coolreaders.com/specifications.asp ) look like one of the standard 6" e-ink screens [
http://www.eink.com/products/matrix/High_Res.html; iRex is not using the same screens as most everybody else]
You can read PDFs on those (I just got one from mybebook.com), but I do not think you're going to be happy reading technical PDFs, or anything 'printed' to A4/U.S.Letter size pages, on those 6" screens.
For freely circulated PDFs, DRM ought to be irrelevant, so the KindleDX may be right for you. Note that the iRex has touch+annotation features that you may need. It's the price of a low-end laptop, but may be worth the investment.
I'd really head over to http://mobileread.com/ and read a bit. You may even get one of the friendly locals to test one of your PDFs ;-). I don't have my iRex yet, it's next in my shopping list ...