Onehub: Why We Chose 960.gs for Our CSS Framework
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If you're set on using a CSS framework, I really think Compass (http://compass-style.org/) is a must. However, the syntax is so wacko I can see anyone's aversion to it.
A definitive solution to this problem has yet to emerge.
But to me, CSS frameworks introduce a lot of cruft to a task that, once learned, is not very difficult. If people are writing stylesheets that are unmaintainable, it means they aren't sufficiently proficient at CSS. I've been there, even after I'd declared I was proficient at CSS. A few years on, my stylesheets are fractions of the size of the ones I used to write and do more than those ones too.