Mozilla Brings Webapps to the Desktop, Challenges AIR, Silverlight
webmonkey.com
webmonkey.com
which I believe runs on Safari/Webkit. It allows for Applescript and plugins.
I know it's hard to build cross-platform stuff, and stuff that tries to look native (Java/Swing, Qt) also fails horribly, but stuff like AIR makes me cringe when I can't use command-a, or control-a/e. I think browsers are relatively good in that regard; at least in Safari I can use all my common shortcuts, even if the web page is created on windows/linux. That sounds logical, but is a huge difference with things like Java, QT, Gtk+, AIR or Silverlight.
EDIT: It's on the wishlist, nice! https://wiki.mozilla.org/prism#Wishlist
For Songza and Pandora, for which I was also using Prism, I've found Xenocode's Virtual Apps to be much better:
http://www.xenocode.com/Music/
I use their Pandora app on a daily basis.
@ellyagg I can understand that not everyone thinks that this technology is a great idea, but for my audience this could be a huge win for me!
I think they're making a big mistake releasing a competitor for the world's best Twitter application platform by not supporting what would be needed to build a Twitter client with it.