Look at this video at 6m30sWhat does that video possibly prove? That if you compare completely different sites, you can't use reductionist measures of individual attributes to compare speed? Is there anyone on HN who actually doesn't already know that? This is asking which of a collection of mystery vehicles is the fastest by engine size, and then revealing that one is a dump truck, one a train, and the other a motorcycle, with results that should surprise no one.
The only people who would possibly be interested in this project are people who are attempting to optimize the experience their app provides, presumably in a holistic fashion. It is pretty much part and parcel that such a person is going to minimize elements, CSS, images, and scripts in such a case, and aren't simply going to replace jQuery with something like this and assumes that it will make everything fast.
The reality of something like jQuery, like Ruby on Rails or MongoDB, is if you start with it you'll likely be stuck with it. You can't simply make a full site and run it through the profiler and swap out components without significant rewriting.