* Realtalk [0].

* FLOSS Weekly [1]. Some great guests, but it's very broad so you might not get what you're looking for every week.

I haven't checked it out yet, but I recently took note of Foodfight [2], looks to be DevOps focused.

0: http://realtalk.io/

1: http://twit.tv/show/floss-weekly

2: http://foodfightshow.org/

CompuCast[0] is by some folks at the University of Edinburgh. They cover mostly academic research, but do a good job of making it accessible for people with a basic background in CS.

0: http://computersciencepodcast.com/

You might like this one, its not pure Computer Science but there is a lot of it. Its by the ThinkRelevance guys, of known for clojure, datomic and pedastal. The also talk about company organisation and things like that.

They had Rich Hickey on multiple times, most recently to talk about core.async the new CSP library.

http://thinkrelevance.com/blog/tags/podcast

I recommend http://realtalk.io/

My two favorites:

http://nodeup.com/ - My personal favorite, great if you are into Node or interested in learning. Lots of interesting podcast topics (promises, performance, scaling websockets, leveldb are some recent ones).

http://thechangelog.com/ - Member support podcast that covers a broad range of popular open source projects and their main contributors.

On a side note, realtalk.io looks interesting as well, I'll have to check that one out too (in addition to thinkdistributed) for my long commutes :)

There are some absolutely awesome episodes on Software Engineering Radio:

http://www.se-radio.net/

There are also some awful ones, but the good ones more than make up for it. For an example of an awesome one, try this:

http://www.se-radio.net/2008/09/episode-109-ebays-architectu...

Another (js-specific) one is [0]JavaScript Jabber. Full disclosure: I am one of the co-hosts of the show, but we usually have much smarter people come on and talk.

0: http://javascriptjabber.com

Accidental Tech Podcast: http://atp.fm/

Debug: http://www.imore.com/debug

StackExchange: http://blog.stackoverflow.com/category/podcasts/

Core Intuition: http://www.coreint.org/

Back to Work: http://5by5.tv/b2w

Going to shamelessly plug the show I host, Techendo (http://techendo.co) -- I'm building the Audio RSS feed tonight.