Not in an insurgency, low-intensity warfare sort of way. Not unless you can somehow make them very targeted.

"We had to destroy the [village] in order to save it" doesn't really apply if you consider, say, New York City.

As https://en.wikipedia.org/wiki/Millennium_Challenge_2002 (and, of course, successful terrorist acts over the last decade) demonstrated, low tech is still Good Enough for a lot of purposes.

Yes, but that's assuming there are people in the government with the will to deploy those weapons against the public. At best they'd only achieve pyrrhic victory.