16MB runtime is really painful. Having to pack a huge amount of the standard library (List is backed by a lot of other traits for example) into the js is going to be very difficult to reduce.
Seeing the presentation, I'm thinking more of using it with something like node-webkit[1] though. Didn't LightTable use clojure-script or something? But then, why don't just use one of JVM's GUI framework?
Also I just want to mention that Clojurescript compiles to javascript that's compatible with Google's Closure compiler, which can do dead code elimination and will remove the parts of the standard library that you don't use.