There is a lot of "affordable" ($400K to $600K) single family homes in the San Fernando Valley, or towards Orange County, so I had a lot of coworkers buy homes in those areas. If you work in Venice, a house in Torrance is about a 45 minute commute by car. I know this will sound absurd to a lot of people in HN, but if you told a Los Angelan your commute to work was 45 minutes each way, they would say "that's pretty good."
However, if you bought a home in Torrance and live there and a company in downtown LA wants to hire you, even though you're only driving about another 8 miles or so, your commute will probably explode close to an hour and a half, and at least one day a week there'll be some clsuterfuck of an accident on one of the freeways, and you'll have the lovely experience of leaving your house at 8:00am and somehow still being late to your 10:00am stand-up meeting. Fun times!
So I saw home ownership cause former coworkers limit their economic mobility to within one section of one city. For them, it was an option to simply wait until a desirable job opened up in the areas with a bad-but-not-intolerable commute, or they were able to mitigate commutes by negotiating flexible hours with their employers (e.g. working 7am to 3pm, or 11am to 8pm, or only coming in 2-3 days a week, etc).
I recognize Los Angeles' traffic is about as bad as it gets as far as a home ownership "anchoring" someone, but if home ownership causes a reduction in mobility for professionals in a high-earning and high-demand field, I can only imagine the kind of impact it has on the rest of America.