But, finding niches of interest to focus on usually helps, as it does when crafting really good songs in a specific style, one that matches your musical abilities and understanding. You may not have the chops, but you can still create amazing work.
With programming, I have the issue of wanting to catch up on everything and do side-projects (eventually, I'll run through this class => http://faculty.cs.byu.edu/~jay/courses/2012/fall/330/course/...), but I have found success in trying to pick-up things in conjunction with a task at hand. If I have to build a web service, I'll start that research simultaneously. Starting IOS work... then spend time with C, understand Objective-C's runtime, read about the history (and play around with Smalltalk). This piece-meal approach seems to make the jump more "doable" in my opinion.
I think that people without a CS degree can obtain a good, challenging gig if they have a good niche to school themselves in, and of course, pick-up the gaps from the people they work along with who have that background/knowledge.