What do you mean? The arabic number system that most of the world uses is base 10. Also, I don't see why the base of the number system would make math any easier or harder.
In Japanese (IIRC), 2, 10, 12, 22 is spoken "ni, ju, ju-ni, ni-ju-ni": "two, ten, two-tens, two-tens-and-two".
It's not that one base is better than another: the idea is that a single consistent base is better than inconsistency.
This really made it simple to think of things like carrying (oh, that's just breaking the wire holding the beads together) and squaring/rooting (since 100 was a square of 10 it was trivial). It provided an interesting method of multiplication too (simply align two numbers orthogonally and fill in the grid). I still think in terms of this now.
Incidentally, when I learned Japanese many years later it felt more natural than saying twenty-two or the abomination that is seventeen.
20 is "esrim", meaning tens, which is actually a special case because Hebrew once had a grammatical dual form. Then comes "shloshim", meaning threes. "Arba'im", fours. And so on. So 22 is "esrim ve'shtayyim", tens and two.
A number like 52347 would be said like "five ten thousands, two thousands, three hundreds, four tens, seven ones"
Of course, this doesn't really apply above the ten thousands. To say 1,000,000 you have to say "one hundred ten thousands".