Interesting, what problems are you trying to avoid?
I don't want to have to work around a framework or have one get in the way. I would rather redo the work, knowing 100% what every line of code in my app is doing. Plus, large frameworks like Django don't even look like Python at times.
If you're intent on understanding 100% of your codebase, you should consider one of the single-file frameworks, like Bottle or Flask, and spend some time reading and understanding their code.