I like ClojureScript and use it a lot lately. Sometimes however it feels a little distant from JavaScript at times. This can be frustrating at times. Wisp is somewhere between ClojureScript and JavaScript.

Of course this means that some of Clojure's features (protocols and lazy sequences, atoms, etc.) are not available. On the other hand there are not so many opaque layers between your code and the target code.

Granted feature-wise it might be more similar to a scheme, but Clojure Syntax is so much more readable and I do not see a point why it would not be a valid approach.