Google App Engine was almost a science project for the first few years, only supporting languages that Google used internally.
Python?
Python?
[UPDATE] According to Wikipedia (judge for yourself), Larry Page is quoted as saying:
"BackRub is written in Java and Python and runs
on several Sun Ultras and Intel Pentiums running Linux."
, back in 1996 whilst he was still at Stanford (Backrub being the original project name).