my whole office use emacs for clojure dev but I use vim. I tried emacs for a few days on more than one occasions but simply couldn't bear the physical awkwardness of the key combos (I did remap ctrl to caps).
I was very unpleasantly surprised when I discovered that OS X uses a single Control key for some of its hotkeys (like C-up/down) which I bind in Emacs for my own purposes.
EDIT: If you really want access to a less crowded namespace, using (global-set-key "\C-z" nil) to free up the c-z prefix and binding Hyper are popular.
If you are feeling a little confined, key chord[1] will allow you to get creative with your bindings.