Well it sort of depends on the makeup of the team. Imagine your on the Starship Enterprise and you have to beam down to an unknown planet. Who do you want on your team? Well you want Kirk, probably a science officer (Spock) maybe the medical officer (Bones McCoy) , possibly the Coms officer (Uhura) and a maybe a RedShirt to get blasted away if you come across some real nasty situation. [0]
So lets assume you are Kirk. The leader, human in touch with his emotions instincts and has the ability to make decisions but passionate and aggressive. Lets assume your other partner is Spock. Total nerd. At best unable to read human nuance, emotion at worst totally miss the poker move Kirk thinks up to save the day. At best he/she coolly out-logics the best Roumlan, Klingon or Borg enemies they face. Then there is Bones. Bones is also all empathy, human and the thinking conscience always trying to get out of sticky situations with the least harm. [1]
For each episode all three at some times came into conflict to resolve a difficult situation. Sometimes it was Spock and Bones butting heads over the most direct decision compared to the decision that caused least harm. Another time it's Spock advising Kirk not to take such rash action as trying to remove all the Tribbles as they do sooth the crew and saved the day as in "The Trouble with Tribbles" [2]
I guess what I'm trying to say is your wife may have the latent skills you need in your team that has to be identified. Identify her character skills. Is it all logical and calm like Spock? Passionate, rash and gambler and decision maker like Kirk? Or is she able to read into people and situations that baffle both Kirk and Spock as Bones can?
You need all three character types to succeed in any Starship (I mean startup) adventure, and YC interviews can also be included. Each personality contribute to produce a successful outcome. Choose the wrong combo and you'll be just another RedShirt in the application process.
PS My experience is that if you can determine this you can work to plug the gaps. Not all people are creators interested in building. But they may be logical analytical and empathetic at the same time.
[0] You can substitute these "old-skool" trekky characters with NexGen Pikard for Kirk, Warf/Data for Spock and maybe Troi for Bones ~ http://en.wikipedia.org/wiki/Star_Trek:_The_Next_Generation
[1] http://en.wikipedia.org/wiki/Star_Trek:_The_Original_Series