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Wow, this is totally awesome. This is my first time hearing about emscripten and I've been a Cocoa and JS programmer for about 9 years.

What are some of the coolest applications of emscripten?

Not sure if this qualifies as 'cool', but I used Emscripten to port parts of OpenSCAD to Javascript http://www.fabfabbers.com/openscad

PDF.js is used by Firefox to render PDFs in the browser.

PDF.js doesn't use emscripten, as far as I can tell.

For a recent example of emscripten, try this one from yesterday: https://news.ycombinator.com/item?id=5673356